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Richter transformation remains an ominous celebration for patients with CLL, specially when it's clonally relevant to the first CLL, due to the fact Not one of the not too long ago permitted novel agents is truly productive. Indeed, ailment transformation is a comparatively prevalent explanation for failure to reap the benefits of these medicines.90,128,129 Histological confirmation is always advised since it can guidebook prognosis (i.e., Hodgkin lymphoma and clonally unrelated tumors have a lot more favorable prognosis).
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